NUMERICAL PREDICTION OF EARLY AORTIC ARCH MORPHOGENESIS AND ARTERIAL MICROSTRUCTURE

Pt, 20/03/2017 - 09:49 — ecem.yazar
20/03/2017 15:00
Turkey

 

 

  
  Embryonic cardiovascular (CV) mechanics is an emerging field that could unravel the interactions between the vessel microstructure and the mechanical loading that govern the prognosis of congenital heart defects. Our laboratory investigates the emergence and extinction of early embryonic aortic arches as they form the mature brachiocephalic arteries, aortic arch and pulmonary arteries during fetal development. Both the soft tissue stresses and hemodynamics play a significant role during this dynamic multi-scale process. In this talk computational embryonic CV tissue growth models that have potential to predict vessel morphology and the physiological vascular stresses will be presented. In these studies, one key challenge involves the drastic variation of homeostatic growth-equilibrium stress states during CV development. Time-lapsed multi-modal experiments performed during critical embryonic development windows offer big data sets for the validation of predictive morphomechanical models. Towards this goal, the experimental findings from micro-pressure, gene expression, optical coherence velocimetry and immunohistochemistry will be presented for embryonic arterial development in the chick embryo. Unlike mature CV systems, the embryonic vasculature represents a primitive, disorganized but highly dynamic soft tissue microstructure.

DOÇ. DR. KEREM PEKKAN
Kerem Pekkan is a faculty member at Koc University Mechanical Engineering Department. He is trained at Middle East Technical University, Purdue University, Georgia Institute of Technology and led his independent research laboratory at Carnegie Mellon University as an Associate Professor. He studies span bio inspired fluid dynamics, embryonic biomechanics and cardiovascular fluid dynamics through particle image velocimetry and computational fluid dynamics. His team focuses pediatric cardiovascular engineering in order to improve the surgical outcome of congenital heart defects. Professor Pekkan authored over 70 peer-reviewed manuscripts and holds three US patents. He is the Associate Editor of Artificial Organs and BMES Cardiovascular Engineering and Technology journals. On 2013 he served as an organizer of the APS Division of Fluid Dynamics meeting. He is supported through US-NSF CAREER, AHA, NIH, TUBITAK and ERC awards.

 

  
  KUZEY KAMPÜS KARE BLOK KİMYA MÜH. BÖL. 4.KAT KB 428