Decades of drug-discovery research have shown that drug molecules that need to cross the cell membrane exhibit a relatively narrow range of physicochemical properties, e.g., molecular mass, hydrophobicity and polarity. A recent survey of a dataset of human approved drugs has found that 27% of these are aliphatic amines and 20% are carboxylic acids [1,2]. In an aqueous environment at neutral pH, aliphatic amines have a propensity to be protonated and carry an electric charge of +1e.